Celebrex (Celecoxib) was introduced in the U. S. in 1999 as a COX-2 inhibitor, which was the first approved in the world to prevent and treat COX-2 deficiency in patients with arthritis. Celebrex is a selective COX-2 inhibitor that selectively inhibits the activity of COX-1 and COX-2 enzymes, reducing the synthesis of prostaglandins and inhibiting their degradation in the gastrointestinal tract. Celebrex has demonstrated efficacy in reducing pain and improving quality of life in patients with arthritis, with fewer side effects, such as gastrointestinal bleeding, which can occur with COX-2 inhibitor treatment.
Celebrex has been used for many years in the management of osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, and osteoarthritis in adults, among others. It is also used as a prophylactic agent in the treatment of rheumatoid arthritis, a condition that can occur in some patients who do not respond to previous therapy. Celebrex has been demonstrated to reduce the risk of developing heart failure in elderly patients, particularly those who have been exposed to COX-2 inhibitors during the initiation of rheumatoid arthritis. Celebrex has been shown to reduce the risk of serious cardiovascular events in patients with coronary heart disease.
Celebrex is a COX-2 inhibitor. Celebrex is an NSAID (Nonsteroidal Anti-Inflammatory Drug) that works by blocking the COX-1 enzyme, which prevents the conversion of cyclooxygenase to prostaglandins, thus reducing the inflammatory response that leads to pain. NSAIDs can also have a direct effect on prostaglandins, but in some patients, they can cause increased GI bleeding, which can be serious. Celebrex is effective for many patients who are at high risk of gastrointestinal toxicity. Patients who are at high risk for cardiovascular events, such as those with a history of cardiovascular disease, should also be cautious in this approach. As with any other medication, Celebrex may cause side effects.
Celebrex is indicated for the treatment of pain in patients with osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. It is indicated for the treatment of osteoarthritis of the knee and hip, as well as the management of patients with arthritis.
Celebrex has several advantages over other NSAIDs. The drug has been shown to reduce the risk of gastrointestinal side effects compared to other NSAIDs. It can also reduce the risk of side effects, such as stomach bleeding, which are associated with NSAIDs. This makes Celebrex a popular choice for those who have difficulty swallowing tablets and for patients who want to take a smaller dose.
Celebrex is available as a capsule, gel, and injection. It is taken orally with or without food. The usual starting dose is 200 mg three times a day. The dosage is based on the patient's age, weight, and risk factors. Patients should take Celebrex at least one hour before or two hours after taking aspirin.
The maximum recommended dose of Celebrex is 100 mg per day, with or without food.
Like all other NSAIDs, Celebrex is known to cause side effects in some patients. These side effects are generally mild and occur at the beginning of the treatment. Common side effects include gastrointestinal bleeding, ulceration, and bleeding in the stomach and intestines. These symptoms can occur at any time while taking Celebrex. Some people experience mild side effects while taking Celebrex, such as gastrointestinal bleeding.
Patients with a history of stomach ulcer, gastrointestinal bleeding, or heart problems should be cautious about taking Celebrex, particularly if they have had a previous history of stomach ulcers or heart failure. Patients who have recently had a heart attack or stroke should avoid taking Celebrex. It is also important to inform your doctor about any medications you are taking, including over-the-counter medicines and herbal supplements.
CELEBREX 200MG CAPSULE contains Celecoxib which belongs to group of medicines called Non-steroidal anti-inflammatory drugs. CELEBREX 200MG CAPSULE is used in adults to manage osteoarthritis (degenerative joint disease), rheumatoid arthritis (inflammatory disease of joints), ankylosing spondylitis (chronic back pain), acute pain and primary dysmenorrhea (menstrual cramps).
CELEBREX 200MG CAPSULE is also used to manage juvenile rheumatoid arthritis (in children aged 2 years and above).
CELEBREX 200MG CAPSULE is not recommended for use in patients allergic to Celecoxib, sulfonamides, aspirin and/or other NSAIDs. It is also not recommended for use in patients with/had a history of an ulcer in stomach/intestines, bleeding in stomach/intestines, blood circulation problems (such as peripheral arterial disease), red itchy welts, inflammatory disease of the intestines (such as ulcerative colitis/Crohn’s disease).
The medicine is also not indicted for use in patients suffering from lung problems (such as asthma), heart diseases (such as heart failure, recent heart attack, heart block), severe liver disease (such as advanced hepatic insufficiency) and/or kidney disease (such as advanced renal insufficiency).
Before taking CELEBREX 200MG CAPSULE, inform your doctor if you have diabetes, raised blood pressure, increased cholesterol, signs of fluid retention (such as swollen ankles and feet) and/or hyperkalemia (increased potassium level in blood).
CELEBREX 200MG CAPSULE is not recommended for use in pregnant and breast-feeding women.
CELEBREX 200MG CAPSULE should be used with caution in children and adolescents (aged 2 to 17 years) to manage only juvenile rheumatoid arthritis and is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.
The most common side effects of taking CELEBREX 200MG CAPSULE are high blood pressure, shortness of breath, sore throat, cough, headache, nausea and dizziness. Consult your doctor if any of these symptoms worsen.
How should I take CELEBREX 200MG CAPSULE?The usual dose of CELEBREX 200MG CAPSULE is 200 mg once daily. The child should be follow up is advised to take this medicine for 7 days for full effect
Uses of CELEBREX 200MG CAPSULE in childrenCELEBREX 200MG CAPSULE is primarily used in managing juvenile rheumatoid arthritis and is advised to be used along with adexate in the treatment of patients with mild to moderate osteoarthritis of the knees of the ankylagonists.
Uses of CELEBREX 200MG CAPSULE in Pakistan:Aceclofenac diethyl ether is also available as monograph, Tata. The use of alcohol in alcohol-induced dysmenorrhea may lead to liver problems. CELEBREX 200MG CAPSULE is classified as non-steroidal anti-inflammatory drug and is approved for use in the treatment of osteoarthritis of knees of the ankylagonists.
Uses ofCelecoxib inPedmatic patients with sleeps most hours.Purpose:Celebrex, like the COX-2 inhibitors, is used in the management of arthritis, and other inflammatory diseases, including rheumatoid arthritis, osteoarthritis, and other conditions. The goal of this study is to evaluate the effectiveness and safety of celecoxib in the treatment of the patients with rheumatoid arthritis.
Materials and methods:This multicenter, open-label, phase 2, double-blind, randomized, placebo-controlled trial was conducted at the University of Texas Southwestern Medical Center, Dallas, and was approved by the Institutional Review Board (IRB) of the University of Texas Southwestern Medical Center. Patients with rheumatoid arthritis and ankylosing spondylitis who were not otherwise adequately controlled with other disease-modifying anti-rheumatic drugs, as well as patients with rheumatoid arthritis who were receiving other therapies for pain and/or inflammation, were included. The primary efficacy variable was the incidence of adverse events (AEs) in the event reporting setting, including headache, fatigue, back pain, dysmenorrhea, muscle pain, fever, nausea, vomiting, and diarrhea. Secondary efficacy variables included the number of patients who withdrew from treatment, number of patients who were not withdrawn, number of patients who withdrew, number of patients who were dropped from the trial, number of patients who were not dropped from the trial, and number of patients who were switched from one study to another. The incidence of the primary efficacy variable was the incidence of AEs in the event reporting setting.
Results:Of the 826 patients who were randomized to receive celecoxib (N=336), 6 of them received placebo. Overall, the mean age was 57.5 years (SD 12.8). The most common AEs were abdominal pain and dysmenorrhea. The most common side effects of celecoxib were headache, dysmenorrhea, back pain, nausea, vomiting, and diarrhea. The incidence of AEs was significantly increased among patients who discontinued celecoxib because of adverse events compared to patients who discontinued the placebo. No AEs were observed among patients who discontinued celecoxib, whereas adverse events were reported more frequently among patients who were on placebo than on celecoxib. The most common AE was headache, which was reported most frequently among patients who withdrew from the trial.
Conclusion:Celebrex is an effective treatment for arthritis and its components are well tolerated.
Celebrex (Celecoxib) is an oral, non-steroidal, oral anti-inflammatory drug (NSAID) used to relieve inflammation and relieve pain associated with arthritis, rheumatoid arthritis, and other inflammatory diseases. Celecoxib is the most widely used NSAID in the management of arthritis and other inflammatory diseases. Celecoxib is approved for the treatment of osteoarthritis, rheumatoid arthritis, rheumatoid arthritis, and ankylosing spondylitis.Celebrex (celecoxib) is an oral, non-steroidal, oral anti-inflammatory drug (NSAID) used to relieve inflammation and relieve pain associated with arthritis, rheumatoid arthritis, and other inflammatory diseases. Celecoxib is approved for the treatment of osteoarthritis, rheumatoid arthritis, and other inflammatory diseases. Celecoxib is the most widely used NSAID in the management of osteoarthritis, rheumatoid arthritis, and other inflammatory diseases. Celecoxib is the most widely used NSAID in the management of inflammatory diseases. Celecoxib is approved for the treatment of rheumatoid arthritis, ankylosing spondylitis, and other inflammatory diseases.Celebrex 100mg tablet to be taken on days when you should be working alongside your primary care doctor. It is important to take the tablet regularly as it helps to reduce the chances of unwanted side effects.
Take the tablet as advised by your doctor, usually every 2 to 3 hours as required. You can take it with or without food.
The dosage depends on how you are using the tablet. Your doctor may increase your dose based on needed medical treatment. However, do not exceed the recommended dose.
Do not use more than about 1,3g of celecoxib unless absolutely necessary. Your doctor may advise you to take it twice a day.
The usual dose is once a day, however, there are also certain patients who may need more doses with their dose. Do not exceed the recommended dose.
The most common side effects of Celebrex 100mg tablet include:
If you experience any of the following symptoms while taking Celebrex, stop taking and seek immediate medical assistance.
If you notice any further side effects not mentioned in the post, or if you experience them, see your doctor.
Some serious side effects of Celebrex 100mg tablet include:
If you experience any of the following side effects, talk to your doctor immediately, including:
The above is not a complete list of possible side effects. If you have any questions about taking any medication, please talk to your doctor. Keep an updated list of all your medicines.
You can follow the instructions of your doctor or pharmacist carefully if you have any doubts about your medication. They may ask you about the possibility of allergic reactions. You should be able to check your own doctor if you are taking any other medicines.
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